Rabbit Monoclonal Antibody to UBE2M

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short~lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin~activating enzymes, or E1s, ubiquitin~conjugating enzymes, or E2s, and ubiquitin~protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin~conjugating enzyme family. The encoded protein is linked with a ubiquitin~like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]