Rabbit Monoclonal Antibody to PVRL4

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin~like (Ig~like) C2~type domains and one Ig~like V~type domain. It is involved in cell adhesion through trans~homophilic and ~heterophilic interactions. It is a single~pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia~syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full~length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]