Rabbit Monoclonal Antibody to Fbx32

This gene encodes a member of the F~box protein family which is characterized by an approximately 40 amino acid motif, the F~box. The F~box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1~cullin~F~box), which function in phosphorylation~dependent ubiquitination. The F~box proteins are divided into 3 classes: Fbws containing WD~40 domains, Fbls containing leucine~rich repeats, and Fbxs containing either different protein~protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F~box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]