Rabbit Monoclonal Antibody to SKP2

This gene encodes a member of the F~box protein family which is characterized by an approximately 40 amino acid motif, the F~box. The F~box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1~cullin~F~box), which function in phosphorylation~dependent ubiquitination. The F~box proteins are divided into 3 classes: Fbws containing WD~40 domains, Fbls containing leucine~rich repeats, and Fbxs containing either different protein~protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F~box, this protein contains 10 tandem leucine~rich repeats. This protein is an essential element of the cyclin A~CDK2 S~phase kinase. It specifically recognizes phosphorylated cyclin~dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S~phase kinase~associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]