Rabbit Monoclonal Antibody to alpha/beta Synuclein

Alpha~synuclein is a member of the synuclein family, which also includes beta~ and gamma~synuclein. Synucleins are abundantly expressed in the brain and alpha~ and beta~synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]