Rabbit Monoclonal Antibody to Fascin

This gene encodes a member of the fascin family of actin~binding proteins. Fascin proteins organize F~actin into parallel bundles, and are required for the formation of actin~based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed~Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]