Rabbit Monoclonal Antibody to AGR3

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol~disulfide interchange reactions. The encoded protein has an N~terminal ER~signal sequence, a catalytically active thioredoxin domain, and a C~terminal ER~retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over~expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]