Rabbit Monoclonal Antibody to CD38

The protein encoded by this gene is a non~lineage~restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'~diphosphate~ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane~bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N~terminal cytoplasmic tail, a single membrane~spanning domain, and a C~terminal extracellular region with four N~glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]