Rabbit Monoclonal Antibody to TIM 3

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4~positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell~mediated immunity to intracellular pathogens and delayed~type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1~specific cell surface protein that regulates macrophage activation, and inhibits Th1~mediated auto~ and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]