Rabbit Monoclonal Antibody to CD41

Integrin alpha~IIb/beta~3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R~G~D in a wide array of ligands. It recognizes the sequence H~H~L~G~G~G~A~K~Q~A~G~D~V in fibrinogen gamma chain. Following activation integrin alpha~IIb/beta~3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.