Rabbit Monoclonal Antibody to BMP2

This gene encodes a secreted ligand of the TGF~beta (transforming growth factor~beta) superfamily of proteins. Ligands of this family bind various TGF~beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide~linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]