Rabbit Monoclonal Antibody to Proteasome 20S alpha 5/PSMA5

The proteasome is a multicatalytic proteinase complex with a highly ordered ring~shaped 20S core structure. The core structure is composed of 4 rings of 28 non~identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin~dependent process in a non~lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]