Rabbit Monoclonal Antibody to PON3

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high~density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low~density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]