Rabbit Monoclonal Antibody to PCBP2

The protein encoded by this gene appears to be multifunctional. Along with PCBP~1 and hnRNPK, it is one of the major cellular poly(rC)~binding proteins. The encoded protein contains three K~homologous (KH) domains which may be involved in RNA binding. Together with PCBP~1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence~specific interaction with stem~loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'~terminal cloverleaf structure. It has also been implicated in translational control of the 15~lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence~specific alpha~globin mRNP complex which is associated with alpha~globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP~1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP~1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]