Rabbit Monoclonal Antibody to Neuropilin 1

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N~terminal extracellular domain, made up of complement~binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane~spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co~receptors; they affect cell survival, migration, and attraction. Some of the ligands and co~receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]