Rabbit Monoclonal Antibody to Syntaxin 1A

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system~specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C~terminal transmembrane domain, a SNARE [Soluble NSF (N~ethylmaleimide~sensitive fusion protein)~Attachment protein REceptor] domain (known as H3), and an N~terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium~dependent fashion and interact with voltage dependent calcium and potassium channels via the C~terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]