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Flow cytometric analysis of hela cells usingProteinase 3 mouse mAb (green) and negative control (red).
Flow cytometric analysis of jurkat cells usingProteinase 3 mouse mAb (green) and negative control (red).
Flow cytometric analysis of NIH3T3 cells usingProteinase 3 mouse mAb (green) and negative control (red).
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Mouse Monoclonal Antibody to Proteinase 3

  • 货号:

    20373
  • 别名:

    PRTN3; ACPA; CANCA
  • 产品上架时间:

    2024-03-04
  • 应用:

    FCM
  • 反应种属:

    Human,Mouse
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P24158
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to Proteinase 3

Description

Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

References

1. Blood. 2007 Dec 1;110(12):4086-95.
2. Clin Exp Immunol. 2006 Jul;145(1):63-70.

Specification

Aliases PRTN3; ACPA; CANCA
Entrez GeneID 5657
Swissprot P24158
clone 3B4
WB Predicted band size 28kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IF 1/50-1/200
FCM 1/200 - 1/400
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#20373