Rabbit Monoclonal Antibody to SFT

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short~lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin~activating enzymes, or E1s, ubiquitin~conjugating enzymes, or E2s, and ubiquitin~protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin~conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up~regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor~suppressor protein p53 and the hypoxia~inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin~activating enzyme and the E3 ubiquitin~protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]