Rabbit Monoclonal Antibody to Bag3

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45~amino acid BAG domain near the C terminus but differ markedly in their N~terminal regions. The protein encoded by this gene contains a WW domain in the N~terminal region and a BAG domain in the C~terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip~repressible manner. [provided by RefSeq, Jul 2008]