Rabbit Monoclonal Antibody to CD11a

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I~domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function~associated antigen~1 (LFA~1), which is expressed on all leukocytes. LFA~1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1~3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]