Rabbit Monoclonal Antibody to TRIM23

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc~binding domains, a RING, a B~box type 1 and a B~box type 2, and a coiled~coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide~binding family of proteins. Its carboxy terminus contains an ADP~ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]