Rabbit Monoclonal Antibody to P4HB

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol~disulfide interchange reactions. The encoded protein has an N~terminal ER~signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX~like domains and a C~terminal ER~retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol~binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]