Rabbit Monoclonal Antibody to ENO1/ENO2/ENO3

This gene encodes alpha~enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha~enolase in addition, functions as a structural lens protein (tau~crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c~myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha~enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]