Rabbit Monoclonal Antibody to PKC theta

Protein kinase C (PKC) is a family of serine~ and threonine~specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium~independent and phospholipid~dependent protein kinase. This kinase is important for T~cell activation. It is required for the activation of the transcription factors NF~kappaB and AP~1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]