Rabbit Monoclonal Antibody to D4 GDI

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras~related small GTP~binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP~binding proteins are active only in the GTP~bound state. At least 3 classes of proteins tightly regulate cycling between the GTP~bound and GDP~bound states: GTPase~activating proteins (GAPs), guanine nucleotide~releasing factors (GRFs), and GDP~dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras~like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]