Rabbit Monoclonal Antibody to WAVE 1

The protein encoded by this gene, a member of the Wiskott~Aldrich syndrome protein (WASP)~family, plays a critical role downstream of Rac, a Rho~family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott~Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]