Rabbit Monoclonal Antibody to VASP

Vasodilator~stimulated phosphoprotein (VASP) is a member of the Ena~VASP protein family. Ena~VASP family members contain an EHV1 N~terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena~VASP proteins to focal adhesions. In the mid~region of the protein, family members have a proline~rich domain that binds SH3 and WW domain~containing proteins. Their C~terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin~extracellular matrix interactions. VASP is regulated by the cyclic nucleotide~dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]