Rabbit Monoclonal Antibody to SF3B1

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre~mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre~mRNA. Splicing factor 3b is also a component of the minor U12~type spliceosome. The carboxy~terminal two~thirds of subunit 1 have 22 non~identical, tandem HEAT repeats that form rod~like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]