Rabbit Monoclonal Antibody to CD3 epsilon

The protein encoded by this gene is the CD3~epsilon polypeptide, which together with CD3~gamma, ~delta and ~zeta, and the T~cell receptor alpha/beta and gamma/delta heterodimers, forms the T~cell receptor~CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal~transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T~cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]