Rabbit Monoclonal Antibody to Cullin 2

Core component of multiple cullin~RING~based ECS (ElonginB/C~CUL2/5~SOCS~box protein) E3 ubiquitin~protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin~conjugating enzyme. The E3 ubiquitin~protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia~inducible factor (HIF).