Rabbit Monoclonal Antibody to HIF1 beta

This gene encodes a protein containing a basic helix~loop~helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand~bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co~factor for transcriptional regulation by hypoxia~inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]