Rabbit Monoclonal Antibody to PI3~Kinase p85 alpha

Phosphatidylinositol 3~kinase phosphorylates the inositol ring of phosphatidylinositol at the 3~prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3~kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]