Rabbit Monoclonal Antibody to ZYX

Focal adhesions are actin~rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc~binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N~terminal proline~rich domain and three LIM domains in its C~terminal half. The proline~rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein~protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion~stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]