Rabbit Monoclonal Antibody to NEDD8 Activating Enzyme E1C

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short~lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin~activating enzymes, or E1s, ubiquitin~conjugating enzymes, or E2s, and ubiquitin~protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin~activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin~like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]