Rabbit Monoclonal Antibody to TRIM24

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin~associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc~binding domains ~ a RING, a B~box type 1 and a B~box type 2 ~ and a coiled~coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]