Rabbit Monoclonal Antibody to Cullin 5

Core component of multiple SCF~like ECS (Elongin~Cullin 2/5~SOCS~box protein) E3 ubiquitin~protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin~conjugating enzyme. The functional specificity of the E3 ubiquitin~protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B~55 kDa protein. May form a cell surface vasopressin receptor.