Rabbit Monoclonal Antibody to Indoleamine 2,3~dioxygenase

This gene encodes indoleamine 2,3~dioxygenase (IDO) ~ a heme enzyme that catalyzes the first and rate~limiting step in tryptophan catabolism to N~formyl~kynurenine. This enzyme acts on multiple tryptophan substrates including D~tryptophan, L~tryptophan, 5~hydroxy~tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T~cell behavior by its peri~cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]