Rabbit Monoclonal Antibody to alpha 1a Adrenergic Receptor

Alpha~1~adrenergic receptors (alpha~1~ARs) are members of the G protein~coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha~1~AR subtypes: alpha~1A, ~1B and ~1D, all of which signal through the Gq/11 family of G~proteins and different subtypes show different patterns of activation. This gene encodes alpha~1A~adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C~termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]