Rabbit Monoclonal Antibody to Cellular Apoptosis Susceptibility

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin~alpha/beta heterodimer. Importin~alpha binds the NLS, while importin~beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin~beta and displaces importin~alpha. Importin~alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS~free importin~alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]