Rabbit Monoclonal Antibody to TAF1C

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA~binding protein (TBP) and three TBP~associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1~specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]