Rabbit Monoclonal Antibody to IKZF3

This gene encodes a member of the Ikaros family of zinc~finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic~specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non~protein coding variants. [provided by RefSeq, Apr 2012]