Rabbit Monoclonal Antibody to HARS

Aminoacyl~tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl~tRNA synthetases. The enzyme is responsible for the synthesis of histidyl~transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head~to~head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]