Rabbit Monoclonal Antibody to PPP4C

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)~alpha signaling, activation of c~Jun N~terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF~kappa~B activation and cell migration. The PPP4C~PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C~PPP4R2~PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser~140 (gamma~H2AFX) generated during DNA replication and required for DNA double strand break repair.