Rabbit Monoclonal Antibody to RNF14

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein~protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR~mediated growth of prostate cancer. This protein also interacts with class III ubiquitin~conjugating enzymes (E2s) and may act as a ubiquitin~ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]