Rabbit Monoclonal Antibody to Adiponectin

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti~diabetic, anti~atherogenic and anti~inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty~acid combustion. Antagonizes TNF~alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF~kappa~B signaling through a cAMP~dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.