Rabbit Monoclonal Antibody to PFKFB3

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose~2,6~bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6~phosphofructo~2~kinase activity that catalyzes the synthesis of fructose~2,6~bisphosphate (F2,6BP), and a fructose~2,6~biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin~dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]