Rabbit Monoclonal Antibody to SF3B3

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre~mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre~mRNA. Splicing factor 3b is also a component of the minor U12~type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3~TAF(II)31~GCN5L acetylase) transcription coactivator~HAT (histone acetyltransferase) complex, and the TFTC (TATA~binding~protein~free TAF(II)~containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]