Rabbit Monoclonal Antibody to FBXL11

This gene encodes a member of the F~box protein family which is characterized by an approximately 40 amino acid motif, the F~box. The F~box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1~cullin~F~box), which function in phosphorylation~dependent ubiquitination. The F~box proteins are divided into 3 classes: Fbws containing WD~40 domains, Fbls containing leucine~rich repeats, and Fbxs containing either different protein~protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F~box, contains at least six highly degenerated leucine~rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono~ and di~methylated lysine~36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]