Rabbit Monoclonal Antibody to GCLC

Glutamate~cysteine ligase, also known as gamma~glutamylcysteine synthetase is the first rate~limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22~p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma~glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]