Rabbit Monoclonal Antibody to Syntrophin alpha 1

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin~associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N~terminal PDZ domain of this syntrophin protein interacts with the C~terminus of the pore~forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase~PMCA4b (plasma membrane Ca~ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long~QT syndrome (LQT) ~ an inherited disorder associated with sudden cardiac death from arrhythmia ~ and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin~related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013]